Zika virus active in early pregnancy
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Researchers at Erasmus MC have discovered the Zika virus in the placenta of an eleven week pregnant woman and in cells of the fetus that are involved in the construction of bones and joints. They thus demonstrate for the first time that the Zika virus can be active outside the central nervous system very early in pregnancy.
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In South and Central America and the Caribbean, an outbreak of Zika virus is currently underway, resulting in children with an abnormally small skull and the Guillain-Barrà © muscle disease. "Until now little is known about the effect an infection with the Zika virus can have in early pregnancy and what consequences this can have on the unborn fetus. We have discovered that the Zika virus can be active not only in nervous tissue but also outside it. That is outside the brain and spinal cord, which has been the subject of much research so far. The virus was found in the layer of dense connective tissue surrounding cartilage of an eleven-week-old fetus, "says Annemiek van der Eijk.
Miscarriage
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Van der Eijk: "It is unknown how often this occurs and whether it can cause a miscarriage. The pregnant woman had a miscarriage, probably because her unborn child was infected with the Zika virus. Other causes for the miscarriage, such as genetic congenital abnormalities and infections are excluded. Also the Zika virus was detectable in her blood for much longer than normal. Normally someone is infected for a week and after that the virus is no longer found in the blood. That this patient If the virus had been in her blood for much longer, it may indicate that the virus was the source in the fetus. This is important information for follow-up testing. "
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Important step
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"The discovery of the virus so early in pregnancy and outside the nervous tissue is an important step in research to gain more insight into the full spectrum of diseases that the Zika virus can cause", says Marion Koopmans, head of the Viroscience department at Erasmus MC. The discovery is described in an online article by the leading scientific journal The New England Journal of Medicine (NEJM).
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"The discovery of the virus so early in pregnancy and outside the nervous tissue is an important step in the research to gain more insight into the full spectrum of diseases that the Zika virus can cause", says Marion Koopmans, head of the Viroscience department at Erasmus MC. The discovery is described in an online article by the leading scientific journal The New England Journal of Medicine (NEJM).